Optimization and validation of bioanalytical SPE - HPLC method for the simultaneous determination of carbamazepine and its main metabolite, carbamazepine-10, 11-epoxide, in plasma

• Main Authors: Jasmina Tonic - Ribarska (Author), Zoran Sterjev (Author), Emilija Cvetkovska (Author), Igor Kuzmanovski (Author), Gordana Kiteva (Author), Ljubica Suturkova (Author), Suzana Trajkovic - Jolevska (Author)
• Format: Book
• Published: University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbamazepine is widely used as an antiepileptic drug in the treatment of partial and generalized tonic-clonic seizures. Carbamazepine 10,11-epoxide is the most important metabolite of carbamazepine, because it is a pharmacologically active compound with anticonvulsant properties. According to that,...