Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.
River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms c...
Saved in:
Main Authors: | Chelsea Fischer (Author), Iosune Ibiricu Urriza (Author), Christina A Bulman (Author), K C Lim (Author), Jiri Gut (Author), Sophie Lachau-Durand (Author), Marc Engelen (Author), Ludo Quirynen (Author), Fetene Tekle (Author), Benny Baeten (Author), Brenda Beerntsen (Author), Sara Lustigman (Author), Judy Sakanari (Author) |
---|---|
Format: | Book |
Published: |
Public Library of Science (PLoS),
2019-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
by: Marc P Hübner, et al.
Published: (2019) -
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.
by: Tony Taldone, et al.
Published: (2010) -
Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.
by: Hanna T Sjoberg, et al.
Published: (2019) -
An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi.
by: Maeghan O'Neill, et al.
Published: (2016) -
In vitro silencing of Brugia malayi trehalose-6-phosphate phosphatase impairs embryogenesis and in vivo development of infective larvae in jirds.
by: Susheela Kushwaha, et al.
Published: (2012)