Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.

• Main Authors: Chelsea Fischer (Author), Iosune Ibiricu Urriza (Author), Christina A Bulman (Author), K C Lim (Author), Jiri Gut (Author), Sophie Lachau-Durand (Author), Marc Engelen (Author), Ludo Quirynen (Author), Fetene Tekle (Author), Benny Baeten (Author), Brenda Beerntsen (Author), Sara Lustigman (Author), Judy Sakanari (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms c...