ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation

• Main Authors: Sonaly Lima Albino (Author), Willian Charles da Silva Moura (Author), Malu Maria Lucas dos Reis (Author), Gleyton Leonel Silva Sousa (Author), Pablo Rayff da Silva (Author), Mayara Gabriele Carvalho de Oliveira (Author), Tatiana Karla dos Santos Borges (Author), Lucas Fraga Friaça Albuquerque (Author), Sinara Mônica Vitalino de Almeida (Author), Maria do Carmo Alves de Lima (Author), Selma Aparecida Souza Kuckelhaus (Author), Igor José dos Santos Nascimento (Author), Francisco Jaime Bezerra Mendonca Junior (Author), Teresinha Gonçalves da Silva (Author), Ricardo Olímpio de Moura (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study proposed the synthesis of a novel acridine derivative not yet described in the literature, chemical characterization by NMR, MS, and IR, followed by investigations of its antileishmanial potential. In vitro assays were performed to assess its antileishmanial activity against <i&...