Impact of 10-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children up to two years of age in Brazil

• Main Authors: Indianara Maria Grando (Author), Camile de Moraes (Author), Brendan Flannery (Author), Walter Massa Ramalho (Author), Marco Aurélio P. Horta (Author), Diana Lucia Moura Pinho (Author), Gilmara Lima Nascimento (Author)
• Format: Book
• Published: Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1678-4464; 10.1590/0102-311X00169913
• Keywords: Streptococcus pneumoniae; Meningitis; Vacunas; Medicine; R; Public aspects of medicine; RA1-1270
• Source: Cadernos de Saúde Pública, Vol 31, Iss 2, Pp 276-284 (2015)

The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children ≤ 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Pre-vaccination (2007-2009) and post-vaccination (2011-2012) periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70/100,000 in 2007 to 1.84/100,000 in 2012, and mortality decreased from 1.30/100,000 to 0.40/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness.