Soft tissue angiofibroma with atypical features

• Main Authors: Suzanna J. Logan (Author), Mark A. Edgar (Author), Anthony P. Martinez (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2214-3300; 10.1016/j.ehpc.2020.200458
• Keywords: Angiofibroma; Soft tissue neoplasms; Aryl hydrocarbon receptor; Nuclear receptor coactivator 2; Pathology; RB1-214
• Source: Human Pathology: Case Reports, Vol 22, Iss , Pp 200458- (2020)

Soft tissue angiofibroma (STAF) is a benign fibrovascular neoplasm with a broad differential diagnosis including both benign and malignant tumors. This report expands the histologic spectrum of STAF with a case showing transition of conventional tumor morphology to distinct area of increased cellularity and cytologic atypia with diffuse, strong desmin expression, but absent myogenin and MYO-D1 expression. Mitotic figures were rare and necrosis was absent. These features have not previously been reported in STAF. A fusion was identified between AHRR and NCOA2 genes, which is a known, recurring feature of STAF. Sixteen months following resection with negative margins, there was no evidence of recurrence. Further reports of STAF showing similar findings with longer clinical follow-up are needed to determine the clinical significance of these results.