Development and Characterization of Cefoxitin Loaded D,L-PLA Nanoparticles

• Main Authors: S.R.P. Machado (Author), R.C. Evangelista (Author)
• Format: Book
• Published: São Paulo State University (UNESP), 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1808-4532; 2179-443X
• Keywords: nanoparticles. controlled release. d,l-pla. cefoxitin. in vitro release.; Pharmaceutical industry; HD9665-9675; Pharmacy and materia medica; RS1-441
• Source: Revista de Ciências Farmacêuticas Básica e Aplicada, Vol 31, Iss 3 (2010)

Nanoparticles containing cefoxitin (CEF) made of D,L-PLA (PLA) were designed by a multiple emulsion/solvent evaporation method. The particles were extensively evaluated in relation to morphology, encapsulation efficiency, drug-polymer interactions as well as in vitro drug release kinetics. Nanoparticles were spherical in shape and isolated, with a mean diameter of about 600 nm. The thermal behaviour (DSC) of CEF-containing nanoparticles suggested that the drug was dispersed at a molecular level within the system. The drug encapsulation efficiency in the system for a CEF concentration of 30 mg/mL was 5.5%, as assessed after the drug extraction, by a validated HPLC method. This low encapsulation efficiency is understandable, since CEF is highly hydrophilic. The in vitro assays showed a strong sustained drug release profile from the nanoparticles with kinetics following pure Fickian diffusion.