Isatin Bis-Imidathiazole Hybrids Identified as FtsZ Inhibitors with On-Target Activity Against <i>Staphylococcus aureus</i>

• Main Authors: Rita Morigi (Author), Daniele Esposito (Author), Matteo Calvaresi (Author), Tainah Dorina Marforio (Author), Giovanna Angela Gentilomi (Author), Francesca Bonvicini (Author), Alessandra Locatelli (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, a series of isatin bis-imidathiazole hybrids was designed and synthesized to develop a new class of heterocyclic compounds with improved antimicrobial activity against pathogens responsible for hospital- and community-acquired infections. A remarkable inhibitory activity agains...