Spectrophotometric Assay of Piperazine hexahydrate in Pharmaceutical Formulation with 3,5- Dinitrosalysilic Acid Reagent

A simple spectrophotometric method for the determination of piperazine hexa- hydrate was developed. The method was based on the proton transfer reaction with 3,5- dinitrosalicylic acid (DNS) in basic solution to form yellow product showing a maximum absorbance at 410 nm with molar absorptivity of 83...

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Bibliographic Details
Main Authors: Usra Al-Neaimy (Author), USRA Al-Neaimy (Author)
Format: Book
Published: College of Education for Pure Sciences, 2020-09-01T00:00:00Z.
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Summary:A simple spectrophotometric method for the determination of piperazine hexa- hydrate was developed. The method was based on the proton transfer reaction with 3,5- dinitrosalicylic acid (DNS) in basic solution to form yellow product showing a maximum absorbance at 410 nm with molar absorptivity of 8350 l/mol.cm . The method is obeyed Beer's law over the concentration range 0.5-20 µg/ml. The average recovery % of the method is 99.12% and RSD % of the method is less than 2%.<br /> The method was applied for the determination of piperazine hexahydrate in pharmaceutical formulation as elixir and the results were in good agreement with the standard addition method .- - - - - - - - - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - -
Item Description:1812-125X
2664-2530
10.33899/edusj.2020.126231.1023