Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents

• Main Authors: Wandong Liu (Author), Caiyun Hou (Author), Jiaming Li (Author), Xiaodong Ma (Author), Yanchun Zhang (Author), Mengqi Hu (Author), Yuanzheng Huang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Twenty novel talmapimod analogues were designed, synthesised and evaluated for the in vivo anti-inflammatory activities. Among them, compound 6n, the most potent one, was selected for exploring the mechanisms underlying its anti-inflammatory efficacy. In RAW264.7 cells, it effectively suppressed lip...