CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

• Main Authors: David Bray (Author), Heather Hook (Author), Rose Zhao (Author), Jessica L. Keenan (Author), Ashley Penvose (Author), Yemi Osayame (Author), Nima Mohaghegh (Author), Xiaoting Chen (Author), Sreeja Parameswaran (Author), Leah C. Kottyan (Author), Matthew T. Weirauch (Author), Trevor Siggers (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Non-coding DNA variants (NCVs) impact gene expression by altering binding sites for regulatory complexes. New high-throughput methods are needed to characterize the impact of NCVs on regulatory complexes. We developed CASCADE (Customizable Approach to Survey Complex Assembly at DNA Elements...