Substance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation
<p class="1">In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of in...
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| Main Authors: | , |
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| Format: | Book |
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Kazimierz Wielki University,
2019-11-01T00:00:00Z.
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| Summary: | <p class="1">In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p<0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p<0.05) and the number of eosinophils by 3 times (p<0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p<0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.</p> |
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| Item Description: | 2391-8306 10.12775/JEHS.2019.09.11.039 |