CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer

• Main Authors: Kathryn AF Pennel (Author), Jean A Quinn (Author), Colin Nixon (Author), Jitwadee Inthagard (Author), Hester C vanWyk (Author), David Chang (Author), Selma Rebus (Author), GPOL Group (Author), Jennifer Hay (Author), Noori N Maka (Author), Campbell SD Roxburgh (Author), Paul G Horgan (Author), Donald C McMillan (Author), James H Park (Author), Antonia K Roseweir (Author), Colin W Steele (Author), Joanne Edwards (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract CXCL8 is an inflammatory chemokine elevated in the colorectal cancer (CRC) tumour microenvironment. CXCR2, the major receptor for CXCL8, is predominantly expressed by neutrophils. In the cancer setting, CXCL8 plays important roles in neutrophil chemotaxis, facilitating angiogenesis, invasio...