LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• Main Authors: Weiwei Ge (Author), Qiaohua Hu (Author), Xiangshao Fang (Author), Juanhua Liu (Author), Jing Xu (Author), Juntao Hu (Author), Xuefen Liu (Author), Qin Ling (Author), Yue Wang (Author), He Li (Author), Ming Gao (Author), Longyuan Jiang (Author), Zhengfei Yang (Author), Wanchun Tang (Author)
• Format: Bog
• Udgivet: BMC, 2019-02-01T00:00:00Z.
• Fag: article
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Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...