LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• Үндсэн зохиолчид: Weiwei Ge (Зохиогч), Qiaohua Hu (Зохиогч), Xiangshao Fang (Зохиогч), Juanhua Liu (Зохиогч), Jing Xu (Зохиогч), Juntao Hu (Зохиогч), Xuefen Liu (Зохиогч), Qin Ling (Зохиогч), Yue Wang (Зохиогч), He Li (Зохиогч), Ming Gao (Зохиогч), Longyuan Jiang (Зохиогч), Zhengfei Yang (Зохиогч), Wanchun Tang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: BMC, 2019-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...