LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• Главные авторы: Weiwei Ge (Автор), Qiaohua Hu (Автор), Xiangshao Fang (Автор), Juanhua Liu (Автор), Jing Xu (Автор), Juntao Hu (Автор), Xuefen Liu (Автор), Qin Ling (Автор), Yue Wang (Автор), He Li (Автор), Ming Gao (Автор), Longyuan Jiang (Автор), Zhengfei Yang (Автор), Wanchun Tang (Автор)
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• Опубликовано: BMC, 2019-02-01T00:00:00Z.
• Предметы: article
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Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...