Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout

• Glavni autori: Yvonne Knopp (Autor), Franziska K. Geis (Autor), Dirk Heckl (Autor), Stefan Horn (Autor), Thomas Neumann (Autor), Johannes Kuehle (Autor), Janine Meyer (Autor), Boris Fehse (Autor), Christopher Baum (Autor), Michael Morgan (Autor), Johann Meyer (Autor), Axel Schambach (Autor), Melanie Galla (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2018-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is particularly unwanted in clinical gene editing strategie...