Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells

• Main Authors: Xingyang Wan (Author), Qian Zhou (Author), Huaxian Chen (Author), Zhen Li (Author), Mianling Mo (Author), Zhimin Liu (Author), Heng Zhang (Author), Zhuojie He (Author), Guozhong Xiao (Author), Yihui Zheng (Author), Hongcheng Lin (Author), Donglin Ren (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Slow transit constipation (STC) is a common gastrointestinal disorder characterized by altered gut microbiota and reduced number of enterochromaffin cells (ECs). Astragaloside IV (AS-IV), a low drug permeability saponin, has showed beneficial effects on patients with STC. However, the speci...