Antimicrobial Susceptibility Testing for <i>Corynebacterium</i> Species Isolated from Clinical Samples in Romania

• Main Authors: Cristiana Cerasella Dragomirescu (Author), Brandusa Elena Lixandru (Author), Ileana Luminita Coldea (Author), Olguta Nicoleta Corneli (Author), Marina Pana (Author), Andi Marian Palade (Author), Violeta Corina Cristea (Author), Ioana Suciu (Author), George Suciu (Author), Loredana Sabina Cornelia Manolescu (Author), Loredana Gabriela Popa (Author), Mircea Ioan Popa (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Antimicrobial resistance is one of the most important public health issues. Besides classical multidrug resistance species associated with medical care involved in superficial or invasive infections, there are strains less commonly associated with hospital or outpatient setting&#8217;s infections. Non-diphtheria <i>Corynebacterium</i> spp. could produce infections in patients with or without immune-compromised status. The aim of our study was to determine the susceptibility to antimicrobial agents to <i>Corynebacterium</i> spp. from clinical samples collected from Romanian hospitalized individuals and outpatients. Twenty Corynebacterium strains were isolated and identified as <i>Corynebacterium striatum</i> (<i>n</i> = 7), <i>Corynebacterium amycolatum</i> (<i>n</i> = 7), <i>C. urealyticum</i> (<i>n</i> = 3), <i>Corynebacterium afermentans</i> (<i>n</i> = 2), and <i>Corynebacterium pseudodiphtheriticum</i> (<i>n</i> = 1). All isolates have been tested for antibiotic susceptibility by standardized disc diffusion method and minimal inhibitory concentration (MIC) tests. Seventeen isolates demonstrated multidrug resistance phenotypes. The molecular support responsible for high resistance to quinolones for ten of these strains was determined by the detection of point mutation in the gene sequence <i>gyrA</i>.

Item Description

2079-6382
10.3390/antibiotics9010031