Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis

• Main Authors: Nesrin M. Hasan (Author), Kelli F. Johnson (Author), Jianyi Yin (Author), Nicholas W. Baetz (Author), Lea Fayad (Author), Vadim Sherman (Author), Sarah E. Blutt (Author), Mary K. Estes (Author), Vivek Kumbhari (Author), Nicholas C. Zachos (Author), Olga Kovbasnjuk (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models are suboptimal with respect to their ability to replicate the human in...