Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B

• Main Authors: R. A. Cardoso (Author), A. A. Melo Filho (Author), M. C. C. Melo (Author), D. M. Lyerly (Author), T. D. Wilkins (Author), A. A. M. Lima (Author), R. A. Ribeiro (Author), G. E. P. Souza (Author)
• Format: Book
• Published: Hindawi Limited, 1996-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005-0.5 μg/kg) evoked a dose-dependent increase in body temperature. The febrile response to 0.5 μg/kg of the toxin...