Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study

Background: This cross-sectional study aims to investigate the retino-choroidal degenerative effects of periodontitis, metabolic syndrome (Mets), and the combination of these diseases using optical coherence tomography (OCT) measurements. Methods: Ninety-two patients selected according to inclusion...

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Main Authors: Hatice Arslan (Author), Nur Yorgancilar (Author), Oguz Kose (Author), Mehmet Gokhan Aslan (Author), Ahmet Altin (Author), Sevda Kurt Bayrakdar (Author), Hatice Yemenoglu (Author), Huseyin Findik (Author), Adnan Yilmaz (Author)
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Published: MDPI AG, 2024-10-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hatice Arslan  |e author 
700 1 0 |a Nur Yorgancilar  |e author 
700 1 0 |a Oguz Kose  |e author 
700 1 0 |a Mehmet Gokhan Aslan  |e author 
700 1 0 |a Ahmet Altin  |e author 
700 1 0 |a Sevda Kurt Bayrakdar  |e author 
700 1 0 |a Hatice Yemenoglu  |e author 
700 1 0 |a Huseyin Findik  |e author 
700 1 0 |a Adnan Yilmaz  |e author 
245 0 0 |a Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study 
260 |b MDPI AG,   |c 2024-10-01T00:00:00Z. 
500 |a 10.3390/dj12110351 
500 |a 2304-6767 
520 |a Background: This cross-sectional study aims to investigate the retino-choroidal degenerative effects of periodontitis, metabolic syndrome (Mets), and the combination of these diseases using optical coherence tomography (OCT) measurements. Methods: Ninety-two patients selected according to inclusion criteria were divided into four groups: systemically and periodontally healthy (control), systemically healthy periodontitis (PD), periodontally healthy metabolic syndrome (MetS), and periodontitis and metabolic syndrome combined (PD-MetS). The systemic inflammatory-oxidative effects of periodontitis and MetS were biochemically evaluated using the serum TNF-α level, IL-1β/IL-10 ratio, and oxidative stress index (OSI: TOS/TAS). Retinal (AMT, pRNFLT, and GCL + T) and choroidal (SFCT) morphometric measurements and vascular evaluations (foveal capillary density) were performed via OCT Angio with swept-source technology. Results: Both periodontitis and Mets cause systemic inflammatory stress characterized by significant increases in the IL-1β/IL-10 ratio and OSI (<i>p</i> < 0.05). Compared to the control group, the AMT was significantly thinner in the MetS group, the pRNFLT was significantly thinner in the PD-MetS group, and the SFCT was significantly thinner in both groups (<i>p</i> < 0.05). The GCL+ was slightly thicker in the Mets groups. (<i>p</i> > 0.05) Foveal capillary density did not differ significantly among the groups. (<i>p</i> > 0.05). Conclusions: Periodontitis-related inflammatory stress alone causes changes in retinal and subfoveal choroidal thicknesses that are not statistically significant. On the other hand, when combined with Mets, it may significantly provoke the retinal neurodegenerative effects of this disease. 
546 |a EN 
690 |a periodontitis 
690 |a metabolic syndrome 
690 |a oxidative stress 
690 |a neurodegeneration 
690 |a optic coherence tomography 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Dentistry Journal, Vol 12, Iss 11, p 351 (2024) 
787 0 |n https://www.mdpi.com/2304-6767/12/11/351 
787 0 |n https://doaj.org/toc/2304-6767 
856 4 1 |u https://doaj.org/article/261077ca29a441ee9c75b3cf7c28cd25  |z Connect to this object online.