Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation

• Main Authors: Su Fu (Author), Chunlin Zhang (Author), Xu Yan (Author), Dongzhe Li (Author), Yongkui Wang (Author), Chao Dong (Author), Zhengming Cao (Author), Yongming Ning (Author), Chenglong Shao (Author), Tengyue Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone tissue engineering-based therapy for bone lesions requires the expansion of seeding cells, such as autologous mesenchymal stem cells (MSCs). A major obstacle to this process is the loss of the phenotype and differentiation capacity of MSCs subjected to passage. Recent studies have suggested tha...