Bioanalytical Assay Development and Validation for the Pharmacokinetic Study of GMC1, a Novel FKBP52 Co-chaperone Inhibitor for Castration Resistant Prostate Cancer

• 主要な著者: Oscar Ekpenyong (著者), Candace Cooper (著者), Jing Ma (著者), Naihsuan C. Guy (著者), Ashley N. Payan (著者), Fuqiang Ban (著者), Artem Cherkasov (著者), Marc B. Cox (著者), Dong Liang (著者), Huan Xie (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-<i>N</i>-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Metho...