Protective Mechanism of Hydrogen Sulfide against Chemotherapy-Induced Cardiotoxicity
Over the past few decades, the number of long term survivors of childhood cancers has been increased exponentially. However, among these survivors, treatment-related toxicity, especially cardiotoxicity, is becoming the essential cause of morbidity and mortality. Thus, preventing the treatment-relate...
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| Main Authors: | , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2018-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Over the past few decades, the number of long term survivors of childhood cancers has been increased exponentially. However, among these survivors, treatment-related toxicity, especially cardiotoxicity, is becoming the essential cause of morbidity and mortality. Thus, preventing the treatment-related adverse effects is important to increase the event free survival during the treatment of cancer in children and adolescents. Accumulating evidence has demonstrated that hydrogen sulfide (H2S) exerts a protective role on cardiomyocytes through a variety of mechanisms. Here, we mainly reviewed the cardioprotective role of H2S in the chemotherapy, and emphatically discussed the possible mechanisms. |
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| Item Description: | 1663-9812 10.3389/fphar.2018.00032 |