Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex.

• Main Authors: Kofi Dadzie Kwofie (Author), Kai Sato (Author), Chizu Sanjoba (Author), Akina Hino (Author), Rieko Shimogawara (Author), Michael Amoa-Bosompem (Author), Irene Ayi (Author), Daniel A Boakye (Author), Abraham K Anang (Author), Kyung-Soo Chang (Author), Mitsuko Ohashi (Author), Hye-Sook Kim (Author), Nobuo Ohta (Author), Yoshitsugu Matsumoto (Author), Shiroh Iwanaga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortality. Existing drugs against VL have limitations, including their invasive means of administration long duration of treatment regimens. There are also concerns regarding increasing treatment relapses a...