Impact of a Novel Anticoccidial Analogue on Systemic <i>Staphylococcus aureus</i> Infection in a Bioluminescent Mouse Model

• Main Authors: Hang Thi Nguyen (Author), Henrietta Venter (Author), Lucy Woolford (Author), Kelly Young (Author), Adam McCluskey (Author), Sanjay Garg (Author), Stephen W. Page (Author), Darren J. Trott (Author), Abiodun David Ogunniyi (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we investigated the potential of an analogue of robenidine (NCL179) to expand its chemical diversity for the treatment of multidrug-resistant (MDR) bacterial infections. We show that NCL179 exhibits potent bactericidal activity, returning minimum inhibitory concentration/minimum bacte...