Improvement in affinity and thermostability of a fully human antibody against interleukin-17A by yeast-display technology and CDR grafting

• Main Authors: Wei Sun (Author), Zhaona Yang (Author), Heng Lin (Author), Ming Liu (Author), Chenxi Zhao (Author), Xueying Hou (Author), Zhuowei Hu (Author), Bing Cui (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies (mAbs) are widely used in many fields due to their high specificity and ability to recognize a broad range of antigens. IL-17A can induce a rapid inflammatory response both alone and synergistically with other proinflammatory cytokines. Accumulating evidence suggests that thera...