The effects of age on antibody response towards COVID-19 vaccination: A Systematic Review
<p class="s9"><span class="s2">Background: </span><span class="s10">M</span><span class="s10">ortality rate </span><span class="s10">of COVID-19 infection is</span><span class="s10"&g...
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Prodi Kesehatan Masyarakat FKM UIN Sumatera Utara Medan,
2023-02-01T00:00:00Z.
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| Summary: | <p class="s9"><span class="s2">Background: </span><span class="s10">M</span><span class="s10">ortality rate </span><span class="s10">of COVID-19 infection is</span><span class="s10">exceptionally high in the older population</span><span class="s10">. Various vaccines are being rapidly developed as an attempt to halt the pandemic. </span><span class="s10">Although vaccination has been effective in reducing mortality and hospitalization rate</span><span class="s10"> in recent months</span><span class="s10">, lower vaccine effectiveness has been reported among older adults</span><span class="s10">.</span></p><p class="s9"><span class="s2">Aim:</span><span class="s10"> This review aims </span><span class="s10">to </span><span class="s10">evaluate and summarize current evidence on the effect of age on antibody response towards COVID-19 vaccines. </span></p><p class="s9"><span class="s2">Methods:</span><span class="s10"> </span><span class="s10">Literature search </span><span class="s10">was conducted on PubMed, Scopus, ScienceDirect and ProQuest</span><span class="s10"> </span><span class="s10">for studies published up to 9</span><span class="s11">th</span><span class="s10"> October 2022</span><span class="s10">. </span><span class="s10">The selected studies were assessed The Joanna Briggs critical appraisal tools.</span><span class="s10"> </span><span class="s10">Qualitative analysis was then performed for the final studies.</span></p><p class="s9"><span class="s2">Result:</span><span class="s10"> A final of 9 studies were included in this review. </span><span class="s10">A majority of the studies evaluated the responses of BNT162b2 or mRNA-1273 vaccine, while 1 study investigated the response towards </span><span class="s10">ChAdOx1 vaccine</span><span class="s10">. </span><span class="s10">Outcomes were measured in term of IgG antibody levels or serum neutralization.</span><span class="s10"> Most studies demonstrated significantly lower antibody response and neutralization </span><span class="s10">in older adults compared to younger vaccinees after administration of first and second vaccine dose. However, two studies reported no significant difference in vaccine response</span><span class="s10">s</span><span class="s10"> across age groups after </span><span class="s10">third dose administration.</span></p><p class="s9"><span class="s2">Conclusion:</span><span class="s10"> T</span><span class="s10">his systematic review highlights </span><span class="s10">lower</span><span class="s10">immunogenicity towards COVID-19 vaccines in older population. Further research into strategies to improve vaccine responses in the elderly is required to pro</span><span class="s10">vide sufficient protection for</span><span class="s10"> this vulnerable group.</span></p><p class="s9"><span> </span></p><p class="s9"><span class="s2">Keywords:</span><span class="s10"> COVID-19 vaccine, </span><span class="s10">antibody, neutralization, age, elderly</span></p> |
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| Item Description: | 2548-2173 2580-281X 10.30829/jumantik.v8i1.13631 |