Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein

• Main Authors: Laura García-Pupo (Author), Lucie Crouzier (Author), Alberto Bencomo-Martínez (Author), Johann Meunier (Author), Axelle Morilleau (Author), Benjamin Delprat (Author), Marquiza Sablón Carrazana (Author), Roberto Menéndez Soto del Valle (Author), Tangui Maurice (Author), Chryslaine Rodríguez-Tanty (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aggregation of Amyloid-β (Aβ) peptides is associated with neurodegeneration in Alzheimer's disease (AD). We previously identified novel naphtalene derivatives, including the lead compound Amylovis-201, able to form thermodynamically stable complexes with Aβ species, peptides and fibrils. As...