Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress

• Main Authors: Yadi Zhong (Author), Yingjian Chen (Author), Zhisen Pan (Author), Kaijia Tang (Author), Guangcheng Zhong (Author), Jingyi Guo (Author), Tianqi Cui (Author), Tianyao Li (Author), Siwei Duan (Author), Xiaoying Yang (Author), Yong Gao (Author), Qi Wang (Author), Dong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) intake leads to excessive NAPQI deposition, stimulating inflammatory and oxidative stress and causing fatal liver injury. However, the detailed molecular mechanism involved is unknown, and effective therapeutic approaches remain insufficient. In this study, we discovered that tr...