Preventing Aggregation of Recombinant Interferon beta-1b in Solution by Additives: Approach to an Albumin-Free Formulation

• Main Authors: Najmeh Mahjoubi (Author), Mohammad Reza Fazeli (Author), Rassoul Dinarvand (Author), Mohammad Reza Khoshayand (Author), Ahmad Fazeli (Author), Mohammad Taghavian (Author), Hossein Rastegar (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Aggregation suppressing additives have been used to stabilize proteins during manufacturing and storage. Interferonβ-1b is prone to aggregation because of being non-glycosylated. Aggregation behavior of albumin-free formulations of recombinant IFNβ-1b was explored using additives such as n-...