Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

• Main Authors: Zoran Todorović (Author), Zorica Nešić (Author), Radan Stojanović (Author), Gordana Basta-Jovanović (Author), Sanja Radojević-Škodrić (Author), Ružca Veličković (Author), Prabal K. Chatterjee (Author), Christoph Thiemermann (Author), Milica Prostran (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% - 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25% - 60% more effective in reduction of tubular necrosis score and fractional excretion of Na+. However, the observed differences do not seem to offer significant advantage in clinical settings. Keywords:: simvastatin, acute pretreatment, ischemia-reperfusion (I/R) renal injury

Item Description

1347-8613
10.1254/jphs.SC0070374