Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment
Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and re...
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| প্রধান লেখক: | , , , , , , , , |
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| বিন্যাস: | গ্রন্থ |
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Elsevier,
2008-01-01T00:00:00Z.
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| 001 | doaj_278b3a7d2e6141f9a3c7aa95c7ff8a2c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zoran Todorović |e author |
| 700 | 1 | 0 | |a Zorica Nešić |e author |
| 700 | 1 | 0 | |a Radan Stojanović |e author |
| 700 | 1 | 0 | |a Gordana Basta-Jovanović |e author |
| 700 | 1 | 0 | |a Sanja Radojević-Škodrić |e author |
| 700 | 1 | 0 | |a Ružca Veličković |e author |
| 700 | 1 | 0 | |a Prabal K. Chatterjee |e author |
| 700 | 1 | 0 | |a Christoph Thiemermann |e author |
| 700 | 1 | 0 | |a Milica Prostran |e author |
| 245 | 0 | 0 | |a Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment |
| 260 | |b Elsevier, |c 2008-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.SC0070374 | ||
| 520 | |a Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% - 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25% - 60% more effective in reduction of tubular necrosis score and fractional excretion of Na+. However, the observed differences do not seem to offer significant advantage in clinical settings. Keywords:: simvastatin, acute pretreatment, ischemia-reperfusion (I/R) renal injury | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 107, Iss 4, Pp 465-470 (2008) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S134786131931401X | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/278b3a7d2e6141f9a3c7aa95c7ff8a2c |z Connect to this object online. |