Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver

• Main Authors: Kenya Kamimura (Author), Takeshi Suda (Author), Guisheng Zhang (Author), Yutaka Aoyagi (Author), Dexi Liu (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of a safe and effective method for gene delivery to hepatocytes is a critical step toward gene therapy for liver diseases. Here, we assessed the parameters for gene delivery to the livers of large animals (pigs, 40-65 kg) using an image-guided hydrodynamics-based procedure that involves...