ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers
Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely rel...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2023-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_27e4080c75d24c9d91fc6f8a9bacae1e | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Reinaldo B. Oriá |e author |
| 700 | 1 | 0 | |a Raul S. Freitas |e author |
| 700 | 1 | 0 | |a Cássia R. Roque |e author |
| 700 | 1 | 0 | |a José Carlos R. Nascimento |e author |
| 700 | 1 | 0 | |a Ana Paula Silva |e author |
| 700 | 1 | 0 | |a João O. Malva |e author |
| 700 | 1 | 0 | |a Richard L. Guerrant |e author |
| 700 | 1 | 0 | |a Michael P. Vitek |e author |
| 245 | 0 | 0 | |a ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers |
| 260 | |b MDPI AG, |c 2023-03-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics15041086 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the developmental trajectories of children with worrisome and often irreversible physical and cognitive faltering. This window of time for microbiota maturation and brain plasticity is key to protecting cognitive domains, brain health, and achieving optimal/full developmental potential. This review summarizes the potential role of promising apoE mimetic peptides to improve the function of the gut-brain axis, including targeting the blood-brain barrier in children afflicted with malnutrition and enteric infections. | ||
| 546 | |a EN | ||
| 690 | |a apoE mimetic peptides | ||
| 690 | |a environmental enteric dysfunction | ||
| 690 | |a blood-brain barrier | ||
| 690 | |a gut-brain axis | ||
| 690 | |a intestinal inflammation | ||
| 690 | |a malnutrition | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 15, Iss 4, p 1086 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/15/4/1086 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/27e4080c75d24c9d91fc6f8a9bacae1e |z Connect to this object online. |