Non-surgical management of advanced ovarian cancer with maintenance PARP inhibitors
The standard of care for advanced ovarian cancer is cytoreductive surgery followed by a platinum-taxane combination with PARP inhibition as a maintenance strategy. In practice, many advanced ovarian cancer patients are older and are either not candidates for surgery or decline surgical intervention....
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| Format: | Book |
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Elsevier,
2024-04-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_281a4c7997e2482d9b16b7dd5fbf9f21 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Taliya Lantsman |e author |
| 700 | 1 | 0 | |a Lily Jia |e author |
| 700 | 1 | 0 | |a Meghan Shea |e author |
| 245 | 0 | 0 | |a Non-surgical management of advanced ovarian cancer with maintenance PARP inhibitors |
| 260 | |b Elsevier, |c 2024-04-01T00:00:00Z. | ||
| 500 | |a 2352-5789 | ||
| 500 | |a 10.1016/j.gore.2024.101340 | ||
| 520 | |a The standard of care for advanced ovarian cancer is cytoreductive surgery followed by a platinum-taxane combination with PARP inhibition as a maintenance strategy. In practice, many advanced ovarian cancer patients are older and are either not candidates for surgery or decline surgical intervention. There are limited data for using PARP inhibitor maintenance in the non-surgical patient population. We describe two cases of patients with advanced-stage ovarian cancer who received platinum-taxane chemotherapy and declined surgical debulking. They were continued on maintenance PARP inhibitors and have no evidence of disease for over four years. | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | ||
| 690 | |a RC254-282 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Gynecologic Oncology Reports, Vol 52, Iss , Pp 101340- (2024) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2352578924000195 | |
| 787 | 0 | |n https://doaj.org/toc/2352-5789 | |
| 856 | 4 | 1 | |u https://doaj.org/article/281a4c7997e2482d9b16b7dd5fbf9f21 |z Connect to this object online. |