Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer
Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the pr...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
ABV-press,
2014-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the proportion of extracellular and membrane proteins constituted 13 %. After using some selection criteria to analyze the findings, the authors present a list of 31 potential biomarkers and describe 12 promising breast anticancer therapeutic targets. |
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| Item Description: | 1994-4098 1999-8627 10.17650/1994-4098-2012-0-2-4-10 |