Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency

• Main Authors: Roberta Resaz (Author), Cristina Vanni (Author), Daniela Segalerba (Author), Angela R. Sementa (Author), Luca Mastracci (Author), Federica Grillo (Author), Daniele Murgia (Author), Maria Carla Bosco (Author), Janice Y. Chou (Author), Ottavia Barbieri (Author), Luigi Varesio (Author), Alessandra Eva (Author)
• 格式: 图书
• 出版: The Company of Biologists, 2014-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Glycogen storage disease type 1a (GSD-1a) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α), and is characterized by impaired glucose homeostasis and a high risk of developing hepatocellular adenomas (HCAs). A globally G6Pase-α-deficient (G6pc−/−) mouse model that shows pathological fe...