The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives
Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dos...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Zaporozhye State Medical University,
2014-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment. Сonclusion. Screening has shown that these class of compounds is promising for further research. |
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| Item Description: | 10.14739/2409-2932.2014.2.26165 2306-8094 2409-2932 |