The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives
Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dos...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Zaporozhye State Medical University,
2014-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_28dcf5e34b23460e853089e5d92b33e8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a I. M. Bilay |e author |
| 700 | 1 | 0 | |a E. O. Mihayluk |e author |
| 700 | 1 | 0 | |a V. V. Parchenko |e author |
| 700 | 1 | 0 | |a A. G. Kaplaushenko |e author |
| 700 | 1 | 0 | |a A. I. Panasenko |e author |
| 700 | 1 | 0 | |a E. G. Knysh |e author |
| 245 | 0 | 0 | |a The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| 260 | |b Zaporozhye State Medical University, |c 2014-08-01T00:00:00Z. | ||
| 500 | |a 10.14739/2409-2932.2014.2.26165 | ||
| 500 | |a 2306-8094 | ||
| 500 | |a 2409-2932 | ||
| 520 | |a Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment. Сonclusion. Screening has shown that these class of compounds is promising for further research. | ||
| 546 | |a EN | ||
| 546 | |a RU | ||
| 546 | |a UK | ||
| 690 | |a Pharmacological Actions | ||
| 690 | |a Drug Screening | ||
| 690 | |a Animal Experimental | ||
| 690 | |a Toxic Hepatitis | ||
| 690 | |a 1 | ||
| 690 | |a 4-triazole | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Iss 2, Pp 57-59 (2014) | |
| 787 | 0 | |n http://pharmed.zsmu.edu.ua/article/view/26165/23623 | |
| 787 | 0 | |n https://doaj.org/toc/2306-8094 | |
| 787 | 0 | |n https://doaj.org/toc/2409-2932 | |
| 856 | 4 | 1 | |u https://doaj.org/article/28dcf5e34b23460e853089e5d92b33e8 |z Connect to this object online. |