Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction

• Huvudupphovsmän: Anatoliy Gozhenko (Författare, medförfattare), Vadym Smagliy (Författare, medförfattare), Inna Korda (Författare, medförfattare), Nataliya Badiuk (Författare, medförfattare), Walery Zukow (Författare, medförfattare), Marta Kovbasnyuk (Författare, medförfattare), Igor Popovych (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Kazimierz Wielki University, 2020-02-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.
• Notes: 2391-8306; 10.12775/JEHS.2020.10.02.026
• Keywords: uricemia; uricosuria; immunity; microbiota; relationships; balneotherapy; humans.; Education; L; Sports; GV557-1198.995; Medicine; R
• Source: Journal of Education, Health and Sport, Vol 10, Iss 2, Pp 212-222 (2020)

<p class="pre" style="text-indent: 18,0000pt; text-align: justify; text-justify: inter-ideograph; background: #f8f9fa;" align="justify"><strong><span style="font-family: 'Times New Roman';">Background.</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> Previously</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">by screening correlation links between uricemia and uricosuria, on the one hand, and immunity and microbiota parameters, on the other, registered in patients </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">with chronic pyelonephritis and</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">cholecystitis in</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">remission</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><strong><span style="font-family: 'Times New Roman';">twice</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> (before and after ten days of balneotherapy), we found that raw uricemia determines by 28% nine parameters of immunity as well as bacteriuria and content in E. coli feces. Uricemia, normalized by sex and age, determines by 25% another constellation of immunity parameters as well as content in E. coli feces with impaired enzymatic activity and Klebsiela&Proteus. Instead, uricosuria determines only four parameters of immunity and only by 11,5%. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">The </span><strong><span style="font-family: 'Times New Roman'; color: #222222;">purpose</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> of this study is to analyze the correlation between individual </span><strong><span style="font-family: 'Times New Roman'; color: #222222;">changes</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> in the two parameter sets caused by balneotherapy.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><strong><span style="font-family: 'Times New Roman';">Material and Methods</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">The</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">object</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">of</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">observation</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">were</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> 34</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">men</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">and</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> 10 </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">women</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">aged</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">24-70</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">years</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">old</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">who</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">came</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">to</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">the</span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">Truskavets</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">' </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">spa</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> for the rehabilitation treatment</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">of </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">chronic pyelonephritis combined with</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">cholecystitis in</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">remission</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. The serum and daily urine levels of the uric acid by uricase method were determined</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt; background: #ffffff; mso-shading: #ffffff;">.</span><span class="15" style="font-family: 'Times New Roman';"> Immune status evaluated on a set of I and II levels recommended by the WHO. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">The condition of microbiota is evaluated on the results of sowing of feces and urine.

</span><strong><span style="font-family: 'Times New Roman';">Results</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">It is found that individual changes in uricemia correlate inversely with changes in the level of T-helpers </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">in </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">blood as well as IgA and IgS in saliva</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">while positively</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> with changes in the level of Monocytes with the almost same force as their static levels. Instead, inverse links with changes in inflammatory markers and positive connections with changes in C</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">I</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">C and T-killers that are absent with respect to static parameters are revealed. However, no association was found between changes in uricemia and the intensity of Staph. aureus phagocytosis by blood neutrophils. Changes in uricosuria correlate with changes in only three immune parameters, and even at the limit of significance. Taking into account other relationships, we find that balneotherapy-induced changes in uricemia and uricosuria determine changes in immune status by 60%. </span><strong><span style="font-family: 'Times New Roman';">Conclusion</span></strong><strong><span style="font-family: 'Times New Roman'; color: #222222;">.</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">Endogenous</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">uric</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">acid</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">has</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">a</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">modulating</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">effects</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">on</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">a</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">number</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">of</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">immune</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">parameters</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">in patients with neuroendocrine-immune complex dysfunction on b</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">ackground of </span><span class="18" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">chronic inflammatory diseases</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">.</span></p>