Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt
A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and...
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| Main Authors: | , , , , |
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| Format: | Book |
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Faculty of Pharmacy, Cairo University,
2013-06-01T00:00:00Z.
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| Summary: | A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and indomethacin (20 mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data. |
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| Item Description: | 1110-0931 10.1016/j.bfopcu.2012.07.003 |