Optimized Probability Sampling of Study Sites to Improve Generalizability in a Multisite Intervention Trial

IntroductionStudies of type 2 translation, the adaption of evidence-based interventions to real-world settings, should include representative study sites and staff to improve external validity. Sites for such studies are, however, often selected by convenience sampling, which limits generalizability...

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Main Authors: Jennifer L. Kraschnewski, MD (Author), Thomas C. Keyserling, MD, MPH (Author), Shrikant I. Bangdiwala, PhD (Author), Ziya Gizlice, PhD (Author), Beverly A. Garcia, MPH (Author), Larry F. Johnston, MA (Author), Alison Gustafson, RD, MPH (Author), Lindsay Petrovic (Author), Russell E. Glasgow, PhD (Author), Carmen D. Samuel-Hodge, PhD, MS, RD (Author)
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Published: Centers for Disease Control and Prevention, 2010-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Jennifer L. Kraschnewski, MD  |e author 
700 1 0 |a Thomas C. Keyserling, MD, MPH  |e author 
700 1 0 |a Shrikant I. Bangdiwala, PhD  |e author 
700 1 0 |a Ziya Gizlice, PhD  |e author 
700 1 0 |a Beverly A. Garcia, MPH  |e author 
700 1 0 |a Larry F. Johnston, MA  |e author 
700 1 0 |a Alison Gustafson, RD, MPH  |e author 
700 1 0 |a Lindsay Petrovic  |e author 
700 1 0 |a Russell E. Glasgow, PhD  |e author 
700 1 0 |a Carmen D. Samuel-Hodge, PhD, MS, RD  |e author 
245 0 0 |a Optimized Probability Sampling of Study Sites to Improve Generalizability in a Multisite Intervention Trial 
260 |b Centers for Disease Control and Prevention,   |c 2010-01-01T00:00:00Z. 
500 |a 1545-1151 
520 |a IntroductionStudies of type 2 translation, the adaption of evidence-based interventions to real-world settings, should include representative study sites and staff to improve external validity. Sites for such studies are, however, often selected by convenience sampling, which limits generalizability. We used an optimized probability sampling protocol to select an unbiased, representative sample of study sites to prepare for a randomized trial of a weight loss intervention.MethodsWe invited North Carolina health departments within 200 miles of the research center to participate (N = 81). Of the 43 health departments that were eligible, 30 were interested in participating. To select a representative and feasible sample of 6 health departments that met inclusion criteria, we generated all combinations of 6 from the 30 health departments that were eligible and interested. From the subset of combinations that met inclusion criteria, we selected 1 at random.ResultsOf 593,775 possible combinations of 6 counties, 15,177 (3%) met inclusion criteria. Sites in the selected subset were similar to all eligible sites in terms of health department characteristics and county demographics.ConclusionOptimized probability sampling improved generalizability by ensuring an unbiased and representative sample of study sites. 
546 |a EN 
690 |a optimized probability sampling 
690 |a study sites 
690 |a multisite intervention trial 
690 |a improve generalizability 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Preventing Chronic Disease, Vol 7, Iss 1 (2010) 
787 0 |n http://www.cdc.gov/pcd/issues/2010/jan/09_0002.htm 
787 0 |n https://doaj.org/toc/1545-1151 
856 4 1 |u https://doaj.org/article/28f6eb3cc15940d0a8f9e98c3bb88e63  |z Connect to this object online.