Combination of Probiotics and Natural Compounds to Treat Multiple Sclerosis via Warburg Effect

• Main Authors: Anjali Kandiruthi Ravi (Author), Saradhadevi Kuppusami Muthukrishnan (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2228-5881; 2251-7308; 10.34172/apb.2022.057
• Keywords: medicinal plants; multiple sclerosis; prebiotics; probiotics; warburg effect; Therapeutics. Pharmacology; RM1-950
• Source: Advanced Pharmaceutical Bulletin, Vol 12, Iss 3, Pp 515-523 (2022)

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS).It is an auto-immune disorder. Its usual symptoms are unique to each person. In MS lesionsvast fractions of pyruvate molecules are instantly transformed into lactate. This reprogrammingmechanism of glycolysis is known as the Warburg effect. MS has no efficient treatment yet.Hence, there is a requirement for profitable immunomodulatory agents in MS. Probioticsperform as an immunomodulator because they regulate the host's immune responses. Itsefficacy gets enhanced for an extended period when it combines with prebiotics. In this review,we focus on the metabolic alterations behind the MS lesions via the Warburg effect, and alsosuggesting, the combined efficacy of prebiotics and probiotics for the effective treatment ofMS without side effects. The Warburg effect mechanism intensifies the infiltration of activatedT-cells and B-cells into the CNS. It provokes the inflammation process on the myelin sheath.The infiltration of immune cells can be inhibited by the combination therapy of probiotics andprebiotics. By this review, we can recommend that the idea of this combinational therapy cando miracles in the treatment of MS in the future.