Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

• Hauptverfasser: Makarand Suresh Gambhire (Verfasst von), Mangesh Ramesh Bhalekar (Verfasst von), Vaishali Makarand Gambhire (Verfasst von)
• Format: Buch
• Veröffentlicht: Universidade de São Paulo, 2011-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factori...