Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

• Váldodahkkit: Makarand Suresh Gambhire (Dahkki), Mangesh Ramesh Bhalekar (Dahkki), Vaishali Makarand Gambhire (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Universidade de São Paulo, 2011-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factori...