Ichthyosis: A Road Model for Skin Research
The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or struct...
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Medical Journals Sweden,
2020-03-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Anders Vahlquist |e author |
| 700 | 1 | 0 | |a Hans Törmä |e author |
| 245 | 0 | 0 | |a Ichthyosis: A Road Model for Skin Research |
| 260 | |b Medical Journals Sweden, |c 2020-03-01T00:00:00Z. | ||
| 500 | |a 0001-5555 | ||
| 500 | |a 1651-2057 | ||
| 500 | |a 10.2340/00015555-3433 | ||
| 520 | |a The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or structural proteins essential for normal skin barrier function. The barrier abnormality per se may elicit epidermal inflammation, hyperproliferation and hyperkeratosis, potentially contributing to the patient's skin symptoms. Despite this and other new knowledge about pathomechanisms, treatment of ichthyosis often remains unsatisfactory. This review highlights a series of approaches used to elucidate the pathobiology and clinical consequences of different types of ichthyosis, and related diseases with the ultimate goal of finding new and better treatments. | ||
| 546 | |a EN | ||
| 690 | |a skin ph | ||
| 690 | |a arci | ||
| 690 | |a human epidermis | ||
| 690 | |a keratins | ||
| 690 | |a ceramides | ||
| 690 | |a therapy | ||
| 690 | |a epidermolytic | ||
| 690 | |a congenital | ||
| 690 | |a keratinocytes | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Dermato-Venereologica, Vol 100, Iss 7, p adv00097 (2020) | |
| 787 | 0 | |n https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3433 | |
| 787 | 0 | |n https://doaj.org/toc/0001-5555 | |
| 787 | 0 | |n https://doaj.org/toc/1651-2057 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2995f841e9b14d26b70a7e4b955c8d47 |z Connect to this object online. |