Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

• Main Authors: Yoann Aldon (Author), Paul F. McKay (Author), Jorge Moreno Herrero (Author), Annette B. Vogel (Author), Réka Lévai (Author), Pauline Maisonnasse (Author), Nathalie Dereuddre-Bosquet (Author), Heinrich Haas (Author), Katalin Fábián (Author), Roger Le Grand (Author), Ugur Sahin (Author), Robin J. Shattock (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein expression compared to mRNA as it replicates wit...