Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern
Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consump...
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| Format: | Book |
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MDPI AG,
2023-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_29c2813ae00c424b9ce40e5d3ae825b1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Beatriz Rodrigues Risuenho Peinado |e author |
| 700 | 1 | 0 | |a Walessa Alana Bragança Aragão |e author |
| 700 | 1 | 0 | |a Cristian dos Santos Pereira |e author |
| 700 | 1 | 0 | |a Diane Cleydes Baia da Silva |e author |
| 700 | 1 | 0 | |a Railson de Oliveira Ferreira |e author |
| 700 | 1 | 0 | |a Antônio Hernandes Chaves-Neto |e author |
| 700 | 1 | 0 | |a Luanna Melo Pereira Fernandes |e author |
| 700 | 1 | 0 | |a Rafael Rodrigues Lima |e author |
| 245 | 0 | 0 | |a Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| 260 | |b MDPI AG, |c 2023-05-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox12051038 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. Thus, 32 male Wistar rats were divided into four groups: control (sedentary animals treated with water); training (trained animals treated with EtOH); EtOH (sedentary animals treated with EtOH); and EtOH + training (trained animals treated with ethanol). EtOH was administered to the animals at a dose of 3 g/kg/day at a concentration of 20% <i>w/v</i> for three consecutive days per week via intragastric gavage. The training was performed on a treadmill for five successive days. At the end of the 4-week experimental protocol, the animals were euthanized, and salivary glands and saliva were collected for oxidative biochemistry analysis. Our results showed that EtOH consumption generated changes in the oxidative biochemistry of the salivary glands and saliva. Thus, it was possible to conclude that moderate physical exercise can significantly recover antioxidant activity, reducing the damage generated by EtOH. | ||
| 546 | |a EN | ||
| 690 | |a alcohol | ||
| 690 | |a binge-drinking | ||
| 690 | |a salivary gland | ||
| 690 | |a moderate physical training | ||
| 690 | |a oxidative biochemistry | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 12, Iss 5, p 1038 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/12/5/1038 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/29c2813ae00c424b9ce40e5d3ae825b1 |z Connect to this object online. |